Distinguished Physician-Scientist, Dr. Mikhail Blagosklonny Talks About Proximal Causes Of Ageing

There have been recent discoveries that are suggesting that aging is not due to molecular damage of any kind. Also, it is not a result of any random damage. There is a relationship between disease and aging, and this is easily apparent. Dr. Mikhail Blagosklonny talks about this in detail. Visit classroomvoices.org to read more about Mikhail.

In cell culture, even if the actual proliferation gets blocked, there will still be active pathways that will be growth-signaling as well as nutrient-sensing. These can include the Target of Rapamycin pathway. It can convert quiescent cells to senescent cells, and there will not be any molecular damage involved. This kind of pathway is present in yeast as well as organismal aging ranging from worms to mammals. This same pathway that is driving developmental growth is later able to drive aging as well as its associated diseases. Dr. Mikhail Blagosklonny says that aging is a useless and unintentional run of developmental programs. Even cellular senescence refers to a continuation of cell growth. This means that over-stimulation will lead to increase in functions. These functions would include secretion by fibroblasts, besides contraction by the arterial smooth muscle cells along with aggregation by platelets. There would be bone resorption by the osteoclasts, along with lipogenesis by fat cells. There can be glycogenesis by liver cells in addition to inflammation by neutrophils as well as phagocytosis by macrophages and such others. Overstimulation can also lead to resistance of cell signal. This can be due to the signaling pathways getting blocked. Hyper-function along with signal-resistance can lead to loss of homeostasis, various diseases, even organ damage and eventual death of the organism. This means that hyper-functions of arterial smooth muscle cells along with macrophages, hepatocytes as well as fat cells, blood platelets besides neurons and fibroblasts and others can lead to age-related blindness, besides gangrenes, renal, heart failure, and cancer. Follow Mikhail on Loop

Chronic inflammation is another example of hyper-function as per Dr. Mikhail Blagosklonny. It is closely associated with aging as well as age-related diseases. With cellular hyper-function being one of the main reasons behind aging, there is a need to look at potential anti-aging agents. These can also include several drugs like rapamycin as well as metformin. Learn more https://www.ncbi.nlm.nih.gov/pubmed/?term=blagosklonny

A New Way To Look For A Lawyer Has Been Introduced

When a legal issue comes up, such as a divorce or landlord-tenant problem, it can be difficult to find a lawyer to address it. The New York State Bar Association has launched a new service, Lawyer Referral and Information Service, which makes it far easier and more convenient. The online portal to this service can be found at https://nysbalris.legal.io, or the service can be reached by phone.

 

This service gives people a low-pressure way to get in contact with a lawyer that has an office near them and experience in whatever legal issue it is that they face. In order to get a referral, the individual fills in their information along with a description of their problem. This confidential information is then reviewed by the State Bar and the person is given the contact information for a nearby attorney. The referral is free and if the person decided to consult with the lawyer it is $35 for the first 30 minutes. The individual is not obligated to retain the lawyer.

 

An attorney in New York that is familiar with the State Bar’s new system is Jeremy Goldstein, the Partner of Jeremy L. Goldstein & Associates, LLC. He has been an attorney for 18 years and earned his law degree at the New York University School of Law. He founded his own law firm in June 2014.

 

Jeremy Goldstein’s specialties include corporate compensation and mergers & acquisitions. He provides his legal advice to corporate management teams and compensation committees when they need is such as when hiring or firing an executive. His advice is also sought when a corporation is bought and the compensation packages of that firm’s executives need to be looked at or changed. The corporations that Jeremy Goldstein has advised includes Sears, Roebuck and Co., Miller Brewing Company, and Goldman Sachs among many others.

 

Fighting For the Rights Of Global Citizens Is Important For George Soros

George Soros has been a follower of the philosophical theory of the open society for many years as he feels this is one of the most important theories in society after he himself was exposed to it as a student studying at the London School of Economics. In terms of the philanthropic work completed by George Soros the Hungarian born U.S. citizen has always felt a kinship with those who are displaced or excluded from the majority within society as he was forced to hide from Nazi German forces who occupied his native Hungary from 1944 to 1945 and murdered more than 500,000 Hungarian Jews who were not as lucky as Soros to survive. Over the course of his successful career that began in 1957 with a planned short term move to Wall Street, George Soros has provided more than $12 billion in funding for philanthropic causes through his own Open Society Foundations and in private funding for good causes across the globe.

Read more: http://www.politico.com/story/2016/07/george-soros-democratic-convention-226267

Many people question why a successful hedge fund manager like George Soros, who is reported by Forbes to have more than $25 billion in personal wealth and owns the Soros Fund Management company with over $30 billion in managed assets, would find so many good causes. The deep sense of closeness George Soros feels to refugees and other marginalized groups in society has led to him seeking to create ways of bringing each and every person into their local community in a bid to change the way the world is seen by all people regardless of age, sex, gender, or religious faith. The Open Society Foundations reports George Soros often finds himself working for the aid of those who are discriminated against within society and are often stripped of their basic human rights, such as Roma groups in Europe who have benefited from the largest integration program in the history of the continent. Read more on NYTimes.com

George Soros developed his initial philanthropic work as a response to the problems being seen in South Africa in the 1970s when the Apartheid program was in operation and the hedge fund manager hoped to provide funding for educational opportunities for those trapped under the regime. The Open Society Foundations was originally created in 1979 by Soros as he sought to develop a new way of educating and integrating as many different groups into society as possible; the group has expanded with the aid of the funding of George Soros to now operated programs in over 100 countries across the globe in a bid to create a new policy for integrating as many people as possible into society to live a healthy, free life with the aid of funding provided by George Soros.

Read more about George’s life story at biography.com

Sam Tabar Appointed as Full Cycle Energy Fund Chief Operating Officer

Having spent a significant portion of his career in the finance sector, Sam Tabar is a highly experienced finance strategist. Meanwhile, Tabar intends to join Full Cycle Energy Fund as the Chief Operation Officer.

Founded in 2013, Full Cycle specializes in waste management by financing projects geared towards addressing global climatic crisis and reduction of carbon emissions. Tabar’s financial and business strategies fit Full Cycle considering his extensive experience in legal work and handling different companies around the world.

Sam Tabar Appointed as Full Cycle Energy Fund Chief Operating Officer

Having spent a significant portion of his career in the finance sector, Sam Tabar is a highly experienced finance strategist. Meanwhile, Tabar intends to join Full Cycle Energy Fund as the Chief Operation Officer. Read more about Sam here: Ex-Merrill’s Tabar Joins Schulte Roth to Advise Hedge Funds

Founded in 2013, Full Cycle specializes in waste management by financing projects geared towards addressing global climatic crisis and reduction of carbon emissions. Tabar’s financial and business strategies fit Full Cycle considering his extensive experience in legal work and handling different companies around the world.

According to Angel.co, Sam Tabar joined the Skadden, Arps, Meagher & Flom LLP in 2001 as an attorney. Later on, he left for Sparx Group (PMA) as the Head of Marketing in the Business Development Division where he worked until 2010.

While at Merrill Lynch, Sam Tabar worked as the Director and Head of Capital Strategy across the Asia-Pacific Region. At Schulte Roth & Zabel LLP, Tabar worked as a Senior Associate between September 2013 and August 2014. As an experienced legal practitioner, Sam Tabar has shown his acumen in handling hedge funds, endowments, foundations, pensions, family offices, global marketing, and compliance issues.

Sam Tabar’s education

Sam Tabar attended Oxford University and Columbia University to pursue a Bachelor degree in Arts and Master’s degree in Law respectively. At Columbia University, Sam Tabar was the Columbia Business Law Journal’s editor. Learn more about Sam Tabar: https://commons.wikimedia.org/wiki/File:Sam_Tabar_Picture.jpg

Currently, Tabar is a licensed attorney with the New York State Bar. Leveraging his financial and legal expertise, Tabar contributes significantly to the Huffington Post.

Furthermore, he serves as the CFO of Awearable Apparel. Here, Sam is responsible for formulating business strategies and initiating capital fundraising.

Besides business, Sam Tabar engages in various communal activities through SheTHINX, a humanitarian organization that empowers women around the world through investments in the feminine hygiene. As a private investor, Sam Tabar invested a lot of resources in Tribute.

Additionally, Sam Tabar has an extensive understanding of different cultures. Not only is Tabar fluent in both French and Japanese, but also understands the French and Japanese cultures as well.

Jason Hope: Changing Technology In Arizona

Jason Hope is a huge advocate of the Internet of Things. He is a writer on all things technology and he is a successful entrepreneur.

At Tech.co, he wrote about the topic of the Internet of Things and called the theory the new wave of advancement that has hit the technology industry. His articles on new technology are highly celebrated. When speaking about Jason Hope’s articles, you have to understand the Internet of Things.

The Internet of Things is a theory that technology that is connected can allow numerous device to be sync with one another. The devices can vary from devices we all use in our daily lives to kitchen appliances, cars, and street lights. The idea is to have all of our devices sync to each other, so we can eliminate waste.

Jason Hope believes that the Internet of Thing has the opportunity to change the way companies and individuals operate. He believes that it also has the potential to be the greatest advancement in the modern technology industry. According to Jason Hope, the Internet of Things is becoming increasingly influential, that it can be the greatest investment for companies all over the world.

Once corporations embrace the Internet of Things, other companies will have to follow the trend. Jason Hope thinks that this will lead to more devices to be connected to each other quicker than expected. Hope has a strong belief that smart technology will shift from being a convenience for many to a way of life for all. He believes that connected devices are the way of the future.

Jason Hope was born and raised in Tempe, Arizona. He currently lives in Scottsdale. He considers himself a futurist. In addition to technology, he has a strong interest in politics in the state of Arizona, as well as the political scene all over the country.

Wen By Chaz Is The Real Deal

Today, the consumer market is saturated with products that are supposed to treat damaged hair. Consequently, it is difficult to wade through all the products that are surfacing in your local drugstore, Amazon web store or beauty supply store. The average woman probably spends countless hours and time trying to find just the right product to treat her damaged hair. Certainly, this was true for the woman that wrote an article for Bustle about her hair raising experience testing Wen by Chaz Cleansing Conditioner on her damaged hair. The Wen by Chaz Dean Cleansing Conditioner is a favorite on those night-time infomercials, but is it the real deal?

Testing Wen by Chaz Dean Cleansing Conditioner

The fact is that every time that you try a new product on your hair, it is a test on effectiveness. However, the woman on the article takes the stress off the readers and takes the product for a spin. She shares her standing on the product with readers that are anxious to learn more about the Cleansing Conditioner that takes the place of several popular hair care products. Was a 7 day test enough? Well, it was certainly enough time for the woman in the Bustle article to test the fig version of the product on her fine, limp hair. The woman finally discovered a product that worked. Now, the fig formula is her go to product for bouncy, shiny hair.

Wen by Chaz Dean

Women are walking around with a big smile on their face because they’ve discovered that the Wen By Chaz Dean Cleansing Conditioner is a hair saver. The product does not contain harsh ingredients. It contains natural ingredients that are designed to nourish and moisturize the hair. Note that the product does not produce lather. This is because it does not contain sulfates, which are responsible for the lather. Sulfates are very harmful to the hair.

For more information, visit the official Wen website and Facebook page.

Subscribe: https://www.youtube.com/user/WenHairCare

 

 

Why Contacting MB2 Dental Is a Great Idea For Anyone

Many people are unaware of the benefits that they can attain from ensuring that they’re doing what they need to do to take care of their teeth. The conditions of one’s teeth plays a vital role in the conditions of their overall health. Thus, it’s often recommended for people to do their due diligence of researching prior to enrolling in a dental clinic’s program of treatments as they can never be sure of whether or not the services that they’ve acquired are truly going to be serving them for what they need.

 

At MB2 Dental, a patient can choose to receive a myriad of different services. They are a great place of employment that offers several options of working in the departments that may be most suitable for you. If you’re unable to find a certain type of dental work that may be offered somewhere, it’s important to know that one place will offer you most services that any dentist should, and that is MB2 Dental.

 

Be sure to contact one of the representatives at the help desk of MB2 Dental so that you can have an appointment set up for you at a time that is most convenient for you as well. The dentists of the organization understand that there are many reasons why someone may need to maintain a flexible schedule. After all, people have lives and part of living them is supporting themselves which often includes activities such as going to school, work, business, or anything else that supports them. MB2 Dental will provide you with a list of options in pertinence to the services you receive and what time the appointment(s) will occur. Now is the perfect time for you to contact a representative to receive an adequate amount of guidance for your needs. You may choose services of having your teeth cleaned, extracted, removed, whitened, and much more. The dentists of the clinic are absolutely professional, skilled, trained, and knowledgeable. Be sure to contact them today. By visiting their website, you will find a vast array of details in pertinence to employment offered by them. If that a position of work is what you are looking for, you have arrived at the best place to begin your journey.

 

Madison Street Capital Plays a Major Role in Arranging Minority Recapitalization for ARES Security Corporation

Madison Street Capital is one of the leading firms in the hedge fund market. For a long time, this private banking firm has served as a financial advisor in arranging subordinated debt investment and minority equity for its clients. Recently, the firm acted as the exclusive financial advisor in arranging minority equity and subordinated debt investment for ARES Security Corporation.

 

Based in Vienna, ARES is a world leader in security risk management. Their flagship products are wide-ranging end-to-end security software services. Madison Street appointed Corbel Structured Equity Partners to provide the minority recapitalization. The announcement about the transaction was made by Madison Street’s CEO, Charles Botchway on January 10, 2016. “It was truly an honor to work directly with Ares Security President and Shareholder Ben Eazzetta in providing this investment,” said Reginald McGaugh, a senior managing director at Madison Street Capital. McGaugh also pointed out that ARES Security Corporation is an exceptional firm which offers high-end suite services vital to the protection of the most crucial assets of the world.

 

“We truly appreciate the team at Madison Street Capital and all the work they completed for us in 2016,” said Eazzetta. He went ahead to express how impressed they were about the entire process which entailed valuation analysis, preliminary due diligence, and the final capital raising process.

 

ARES Security Corporation determined that associating with Corbel Structured Equity Partners to innovatively structure their business was the best move as it would establish a considerable equity value. ARES is looking to benefit from Corbel’s operationally supportive partnership and flexible capital solution to maintain its sales momentum. This partnership will also enable ARES to benefit from Corbel’s industry contacts to generate new revenue opportunities.

 

About Madison Street Capital

 

Madison Street Capital is a Chicago-based boutique investment banking firm that offers financial advisory solutions. They specialize in capital restructuring, mergers and acquisition, buyout, bankruptcy, reorganization, and private placement advisory services.

 

The firm has been in operation for more than ten years. Since its inception, it is committed to the virtues of excellence and integrity, particularly when offering corporate advisory services to its clients. The hardworking executives and employees have greatly enhanced Madison Street Capital reputation. The firm is headquartered in Chicago but has branches in North America, Asia, and Africa.

Follow Madison Street Capital on Facebook for updates.

 

Why Everybody Is Quenching the Hawaiian Way

It is now five years since Ryan Emmons partnered with Meyer to create bottled water company, Waiakea Water, which would then grow by over 4000% in the first three years of market life, surpassing the founders’ earlier projections. The company has set up a new manufacturing facility to meet the ever-rising demand from the thirsty market.

But make no mistake, this is no pure accident. Ryan Emmons must have surprised himself when the thought of venturing into bottled water business hit him. I can picture him holding a bottle of clean and nourishing Hawaiian water and thinking of sharing it with the whole world. Success is for the bold, they say.

Today, Emmons’ company is operating internationally, in more than four countries across the breadth of two continents. If this isn’t remarkable achievement, then I don’t know what is. A year ago, the company was valued at more than $10 million.

Baby Boomster revealed that there are several reasons that make Waiakea Water supreme. The water is mined from the cleanest source ever known, Mauna Loa volcano. The water is harvested through snowmelt and rain. The water collects important minerals like calcium, magnesium, and potassium from the volcanic rocks on the Mauna Loa Volcano.

These minerals help to keep the body strong and healthy. Waiakea Water is also rich in electrolyte and alkaline. Alkaline is a recommended remedy for osteoporosis and acid reflux. Waiakea Water also boasts of a smooth taste that is strictly speaking unparalleled.

The bottled water company also uses environment-friendly methods. Utilization of recycled bottles that uses less energy to manufacture and the transportation of water from the Mauna Loa Volcano source to the co-packing plant in Long Beach, California employs the safety of stainless steel tanks. Learn more about more Waiakea Water: https://globenewswire.com/news-release/2015/10/27/780527/10154219/en/Waiakea-Hawaiian-Volcanic-Water-Sees-a-5-000-Percent-Growth-in-Just-Three-Years.html

Another selling point is the fact that Waiakea Water costs less than other bottled water brands and their model is built on the core principles of health, sustainability, and ethics. It is as nourishing and refreshing as it is affordable. Many shop outlets are now stocking the brand, including Whole Foods. This is so because of an upsurge in brand loyalty figures.

Ryan Emmons is also very philanthropic. According to PR News Wire, through the charity PumpAid, Waiakea Waterworks in close collaboration with disadvantaged communities in Africa to provide clean drinking water. By mid-2016, the company had established over 3,500 elephant pants, serving a population of over 1.35 million.

The company has placed itself strategically in the market, and ‘rapid success’ seems to be the only befitting descriptive words for them. Waiakea water is certified CarbonNeutral®.

 

Dr. Avi Weisfogel Aids in Advancements of Sleep Apnea Research and Solutions

In the medical profession, the destructive parts of sleep apnea have become clearer than ever before, for this reason, you are more likely to understand its effects on the renewed spirit of research into this medical condition, sleep apnea, for a long time, has been a killer disease. For this reason, people have developed treatment strategies that work to meet the needs of the individuals in a market fire and situation. Sleep apnea poses a serious threat the life of a patient suffering from the medical condition. For this reason, many therapies have been developed by the Dental Sleep Masters Company and accurate towards its schedule in this regime. For those who are suffering from the illness, treatment therapies can help reduce the effects of the disease while we have no cure confirmed for this disease. Dr. Avi Weisfogel has worked to enrich his mind with the necessary knowledge and innovation to develop these therapies in a manner that is unprecedented in this industry.

Dr. Avi Weisfogel founded the Dental Sleep Masters Company to enrich his foundation of developing related therapies in this arena. For this reason, few people work to meet this calling. According to him, nothing gives him much honor than to become part of the solution to a killer disease. For this reason, he has dedicated all his life to helping patients fight the medical condition in a manner that is determined in this industry. According to a recent study conducted by the Dental Sleep Masters Company based in the United States, more than 90 percent of patients with this disease. Many of them are not diagnosed before they develop serious complications.

When we look at the occurrence of the disease, the sphincter muscles work to develop the higher capability to failure. During sleep, a patient will realize that breathing is decelerated. For this reason, they are necessitated to develop higher mechanical capabilities. They also end up failing in duty and working statements. In the end, you will have your sleep disturbed for the entire part of the night. Therefore, this disease worsens. Its key features are daytime drowsiness. Ensure you get fast attention.

Source: http://www.mtv.com/artists/avi-weisfogel/biography/