There have been recent discoveries that are suggesting that aging is not due to molecular damage of any kind. Also, it is not a result of any random damage. There is a relationship between disease and aging, and this is easily apparent. Dr. Mikhail Blagosklonny talks about this in detail. Visit classroomvoices.org to read more about Mikhail.
In cell culture, even if the actual proliferation gets blocked, there will still be active pathways that will be growth-signaling as well as nutrient-sensing. These can include the Target of Rapamycin pathway. It can convert quiescent cells to senescent cells, and there will not be any molecular damage involved. This kind of pathway is present in yeast as well as organismal aging ranging from worms to mammals. This same pathway that is driving developmental growth is later able to drive aging as well as its associated diseases. Dr. Mikhail Blagosklonny says that aging is a useless and unintentional run of developmental programs. Even cellular senescence refers to a continuation of cell growth. This means that over-stimulation will lead to increase in functions. These functions would include secretion by fibroblasts, besides contraction by the arterial smooth muscle cells along with aggregation by platelets. There would be bone resorption by the osteoclasts, along with lipogenesis by fat cells. There can be glycogenesis by liver cells in addition to inflammation by neutrophils as well as phagocytosis by macrophages and such others. Overstimulation can also lead to resistance of cell signal. This can be due to the signaling pathways getting blocked. Hyper-function along with signal-resistance can lead to loss of homeostasis, various diseases, even organ damage and eventual death of the organism. This means that hyper-functions of arterial smooth muscle cells along with macrophages, hepatocytes as well as fat cells, blood platelets besides neurons and fibroblasts and others can lead to age-related blindness, besides gangrenes, renal, heart failure, and cancer. Follow Mikhail on Loop
Chronic inflammation is another example of hyper-function as per Dr. Mikhail Blagosklonny. It is closely associated with aging as well as age-related diseases. With cellular hyper-function being one of the main reasons behind aging, there is a need to look at potential anti-aging agents. These can also include several drugs like rapamycin as well as metformin. Learn more https://www.ncbi.nlm.nih.gov/pubmed/?term=blagosklonny